What is the recommended treatment for uncomplicated genital chlamydial infection in pregnant women?

The recommended treatment for uncomplicated genital chlamydial infection in pregnant women is a regimen that effectively targets the causative organism, Chlamydia trachomatis, while also considering safety during pregnancy. The combination of erythromycin, 500 mg orally for 7 days or amoxicillin, 500 mg for 7 days is preferred. Both medications are safe for use in pregnancy and have shown to be effective in eradicating the infection.

Erythromycin is an appropriate choice because it is a macrolide antibiotic that has good activity against Chlamydia and is well-tolerated during pregnancy. Amoxicillin, a penicillin derivative, is also effective against chlamydia and has a long history of safety in pregnant populations, making it a viable alternative.

Other regimens, such as those containing tetracycline, are contraindicated in pregnancy due to their association with potential adverse effects on fetal development, including effects on bone and teeth. Likewise, options like ofloxacin, which belongs to the fluoroquinolone class, are also avoided in pregnancy due to safety concerns.

Therefore, the focus on using erythromycin or amoxicillin highlights the importance of both treatment effectiveness and maternal-fetal safety in the management of chlam